Scientists believe they’ve developed You can find more information at vaccine That will result in blockage fentanyl from entering the brain and stop users from getting high — a breakthrough being hailed as a “game changer” In the fight against opioid overdose.

The following was tested on rats vaccine “produced significant amounts” Anti-fentanyl According to a study, antibodies that held on to deadly synthetic opioids were found to be resistant to them. printed in the journal Pharmaceutics.

This prevented the drug from being manufactured. “from entering the brain, allowing it to be eliminated out of the body via the kidneys,” said lead author Colin Haile of the University of Houston’s Drug Discovery Institute.

“Thus, the individual will not feel the euphoric effects and can ‘get back on the wagon’ to sobriety,” Haile predicts it “could have a significant impact on a very serious problem plaguing society for years.”

Colin Haile, lead author, hopes that the vaccine “could have a significant impact on a very serious problem plaguing society for years.”

Fentanyl can be taken up to 50 times stronger than heroin, and a dose of only 2 milligrams — the size of two grains of rice — can prove fatal.

According to the Centers for Disease Control and PreventionMore than 71,000 Americans were killed in this tragedy. fentanyl overdoses last year — almost 195 a day — by far the biggest cause of the overall 107,622 fatal overdoses.

The vaccine’s preclinical results “demonstrate efficacy in neutralizing” fentanylIt can be made into a book. “a potential therapeutic for [overuse] and overdose in humans,” According to the study.

Another of the Texas university’s professors involved in the study, Therese Kosten, called it a potential “game changer.”  

“Fentanyl use and overdose is a particular treatment challenge that is not adequately addressed with current medications,” Kosten said.

Fentanyl.
Fentanyl, which is 50 times stronger than heroin, killed more than 71,000 people in the US last fiscal year.
Getty Images/iStockphoto

These treatments are temporary and require multiple doses. Kosten stated that the cost of these treatments is high. vaccine It would also function as a “relapse prevention agent,” According to the study.

The team is planning to start producing clinical-grade vaccines in the next months and then to conduct human trials.

Researchers concluded that vaccine It did not have any side effects on the rats it was given to, and the positive results were not disputed. fentanylLow doses that are safe and effective for blocking were the culprits.

They also “expect minimal side effects in clinical trials” Because the main components have been extensively tested and are widely used.

Additionally, the antibodies proved to be specific to fentanylSignificance “a vaccinated person would still be able to be treated for pain relief with other opioids,” Haile noted.